PharmD_Rodriguez said:Steady state is the thing most people miss.
That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.
Correct me if the detail matters more than I have assumed.
julia.endo said:All true, with one condition: that curve is for people who reached the dose on schedule.
That reframing is the part I needed.
PharmD_Rodriguez said:Steady state is the thing most people miss.
I read this differently from PharmD_Rodriguez, on substance rather than tone. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
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Browse GL BiochemAdding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
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