Dr.SleepRoch said:The useful move here is to separate what is established from what is widely repeated.
There is a second half to this that has not been said yet. Steady state is the thing most people miss. The terminal half-life is about a week, so every dose step takes four to five weeks to fully express itself. Judging a step at day ten is judging the ascent, not the plateau, and it is the single commonest reason people escalate before they needed to.
Adding the numbers, since they settle part of this. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.
A narrower follow-up, since the general answer is now clear:
What the dose-response curve actually looks like above 1.7mg, because the trial means hide how few people account for the extra loss?
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View ResultsPeptideSynthNJ said:If you are going to change something, change one thing and give it long enough to express itself.
I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.
PeptideSynthNJ said:If you are going to change something, change one thing and give it long enough to express itself.
True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.