LindaRN_retired said:Start from the measurement rather than the conclusion.
Adding the part of the answer the thread has not reached. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
Adding the numbers, since they settle part of this. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.
A narrower follow-up, since the general answer is now clear:
How much of the SELECT benefit is plausibly independent of the weight loss, and whether that distinction changes anything practical?
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Shop Reference Standardsjosh_phd_bmore said:If you are going to change something, change one thing and give it long enough to express itself.
This is where I part company with the consensus forming above. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.
josh_phd_bmore said:If you are going to change something, change one thing and give it long enough to express itself.
Right, and the exception is worth naming rather than left implied, because the exception is where people get into trouble.