Dr.PeteFamMed said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.
Dr.ObesityMed said:The pharmacokinetics explain nearly every practical question asked here.
Bookmarking. The distinction being drawn above is the one nobody else makes. Printing the relevant bit and taking it with me.
Dr.PeteFamMed said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.
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Browse GL BiochemOne concrete data point for the thread. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.
Happy to go further on any of that.
Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Report rather than reply if it drifts again.