sophie_paris said:Heartburn management on constipation: Tums as needed has been my savior.
Sulfur burps on constipation — the most underrated side effect nobody warned me about. 🤢 The smell is absolutely vile and comes on without warning.
What finally helped: taking a digestive enzyme supplement. Also, eating smaller portions and chewing thoroughly reduces the gas production.
If sulfur burps persist beyond 2-3 weeks, talk to your provider — it could indicate gastroparesis that needs medical attention.
stefan_berlin said:Acid reflux and constipation: I developed GERD symptoms around week 6 that I'd never had before.
That reframing is the part I needed. I will report back once I have actually tried it.
sophie_paris said:Heartburn management on constipation: Tums as needed has been my savior.
Gastric emptying studies and constipation: semaglutide delays gastric emptying by ~40% at steady state, as measured by acetaminophen absorption testing and scintigraphy[1].
Clinically relevant implications:
- Explains early satiety and nausea
- Affects absorption of co-administered oral medications
- Creates aspiration risk for procedures under anesthesia
- Contributes to constipation via slowed GI transit
Importantly, the gastric emptying delay attenuates with continued use (tachyphylaxis), which correlates with the transient nature of GI side effects.
[1] Blundell J, et al. Diabetes Obes Metab. 2017;19(9):1242-1251.
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