Read the primary source rather than the write-up and the two do not agree, so here is what is actually in it.
The class is not used in pregnancy, and the practical points are a washout before conception and the fact that reduced appetite is not contraception. Improved insulin sensitivity in PCOS can restore ovulation, so fertility frequently increases as a side effect — people conceive unexpectedly on these drugs, which is a reason to sort contraception out at the start rather than after.
Where I think it is weakest: the comparator does most of the work in how this gets reported, and it is not the comparator most people think they are citing.
The narrow version of the question is what the washout thinking is before trying to conceive, and why nobody mentions that fertility often increases as a side effect. Practical detail welcome, however dull — the duller the better.
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
MeganSA_TX said:The class is not used in pregnancy, and the practical points are a washout before conception and the fact that reduced appetite is not contraception.
MeganSA_TX said:...everyone should be on fertility and pregnancy...
I understand the enthusiasm, but "everyone" is too broad. Contraindications exist: personal/family history of MTC or MEN2, history of pancreatitis, pregnancy/breastfeeding, and certain GI conditions.
Beyond contraindications, clinical judgment matters. A 22-year-old with BMI 28 and no comorbidities has a different risk-benefit calculation than a 55-year-old with BMI 38 and metabolic syndrome.
Let's advocate for ACCESS without advocating for UNIVERSAL use. They're different things.
MeganSA_TX said:The class is not used in pregnancy, and the practical points are a washout before conception and the fact that reduced appetite is not contraception.
I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.
PeptideDetective — Independent Peptide Analytics
Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.
View ResultsAnswering the narrow version, because the broad one does not have a single answer. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.
InsuranceTom said:MeganSA_TX said: ...everyone should be on fertility and pregnancy...
Mine went the same way, slower. Posting only so the count is not one.