Triglycerides dropped by half, HDL barely moved, and my calculated LDL is almost exactly where it started, which is not the outcome I had been promised.
What I am after is whether an unchanged LDL-C alongside a large triglyceride fall is a good result or a bad one, because ApoB and LDL-C seem to be telling different stories.
If the honest answer is that nobody knows, that is a useful answer and I would rather have it.
LipidDoc_ATL said:Triglycerides dropped by half, HDL barely moved, and my calculated LDL is almost exactly where it started, which is not the outcome I had been…
Omega-3 index improvement on the lipid panel: often overlooked but my omega-3 index went from 4.0% to 8.0% over 13 months. I supplemented with 2g EPA+DHA daily.
This matters because omega-3s are anti-inflammatory and cardioprotective, complementing the GLP-1 benefits. Target omega-3 index is >8%. Combined with the triglyceride reduction from the medication, my lipid profile is the best it's been in decades.
LabKate said:Omega-3 index improvement on the lipid panel: often overlooked but my omega-3 index went from 4.0% to 8.0% over 13 months.
Before/after bloodwork compilation for the lipid panel — everything in one place for those who want comprehensive data:
| Category | Marker | Before | After 10mo | Change |
|---|---|---|---|---|
| Metabolic | A1C | 7.4% | 5.6% | ⬇️ 1.6% |
| Metabolic | Fasting Glucose | 132 | 87 | ⬇️ 32 |
| Lipids | LDL | 170 | 99 | ⬇️ 42 |
| Lipids | Triglycerides | 242 | 122 | ⬇️ 92 |
| Inflammation | hsCRP | 7.5 | 1.0 | ⬇️ 5.0 |
Every single metabolic marker improved. This is why I'm a believer in this therapy.
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Browse GL BiochemLipidDoc_ATL said:Triglycerides dropped by half, HDL barely moved, and my calculated LDL is almost exactly where it started, which is not the outcome I had been…
Mine went the same way, slower.
Clinical perspective, offered as context rather than as advice.
Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel:
| Marker | Baseline | Month 8 | Clinical Meaning |
|---|---|---|---|
| LDL-P | 1549 | 949 | Particle count (more precise than LDL-C) |
| Small dense LDL | 59% | 33% | Atherogenic pattern |
| Remnant cholesterol | 33 | 18 | Triglyceride-rich lipoproteins |
| oxLDL | 74 | 47 | Oxidative stress marker |
The shift from small dense to large buoyant LDL is particularly important — it represents a fundamental change in the atherogenic profile.