DebRD_ATL said:The version of this that has an answer is narrower than the version being asked.
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
KristenIndy said:Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak.
Bookmarking. The distinction being drawn above is the one nobody else makes. Adding it to my notes with a link back to this thread.
DebRD_ATL said:The version of this that has an answer is narrower than the version being asked.
Pushing back on DebRD_ATL here. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
I would rather be corrected than agreed with, if it comes to it.
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View ResultsAdding the numbers, since they settle part of this. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.
Moderator note: leaving this open. It is being argued well and the disagreement is the useful part.