hyun_seoul said:The gap between trial results and real-world results is consistent and it is not fraud.
Agreed, and subgroup analyses deserve particular suspicion. With enough subgroups something is significant by chance, and pre-registered subgroups are a different animal from ones found afterwards.
mike.trainer_LA said:Agreed on the mechanism, with the caveat that the head-to-head used semaglutide 1mg, not 2.4mg.
Bookmarking. The distinction being drawn above is the one nobody else makes. I will report back once I have actually tried it.
hyun_seoul said:The gap between trial results and real-world results is consistent and it is not fraud.
I read this differently from hyun_seoul, on substance rather than tone. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.
That is the short version; the long version is somebody else's post.
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Browse GL BiochemOne concrete data point for the thread. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.