Dr.ReproEndo said:The useful move here is to separate what is established from what is widely repeated.
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
ChrisMacros said:Steady state is the thing most people miss.
Saving this. It is the first explanation that did not require me to already understand it. Printing the relevant bit and taking it with me.
Dr.ReproEndo said:The useful move here is to separate what is established from what is widely repeated.
This is where I part company with the consensus forming above. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
Correct me if the detail matters more than I have assumed.
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View ResultsAdding the numbers, since they settle part of this. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.