CarlaRPh_TPA said:Steady state is the thing most people miss.
I read this differently from CarlaRPh_TPA, on substance rather than tone. The affordability discussion here usually stops at individual tactics. At list price this class is out of reach for most of the people who would benefit, and no amount of appeal strategy changes that — it is a pricing problem wearing a paperwork costume.
I would rather be corrected than agreed with, if it comes to it.
The figures, for anyone assembling their own picture. For anyone assembling their own picture: Tmax is one to three days, terminal half-life about 165 to 170 hours, steady state at four to five weeks, and subcutaneous bioavailability near 89%. Those four numbers explain most of the questions people ask about timing.
PurityPaulOR said:The affordability discussion here usually stops at individual tactics.
Coming at PurityPaulOR’s question from a different direction. Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak. People who dose late are not losing a peak, they are letting the trough fall, and the appetite effect tracks the trough.
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Browse GL BiochemA narrower follow-up, since the general answer is now clear:
Whether anyone has held at a sub-maximal dose long term and kept the result, or whether the maintenance data only exists at 2.4mg?
Reporting back.
Update: approved on the third attempt after a peer-to-peer. Nothing about my case changed; only who was doing the talking.