mona_PHX said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.
Closing the loop on my own question.
For the archive: it took about six weeks rather than the two I expected, and the difference between those two numbers was the whole of my problem.
Clinical perspective, offered as context rather than as advice. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.
Sigma-Aldrich — Research-Grade Standards
Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.
Shop Reference Standardstraveltech_sara said:The mechanism and the magnitude are separate questions.
Same experience, arrived at from the opposite direction. Nothing to add that would improve it.
traveltech_sara said:The mechanism and the magnitude are separate questions.
There is a second half to this that has not been said yet. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.