Previously posted:Weeks 1-4 (0.25mg): This is your "get used to it" phase. Honestly, at this dose most people feel very little.
This is so helpful, thank you!! Quick question — does it matter what time of day you inject? My doctor said once a week but didn't specify morning vs evening. I've seen some people say evening is better for managing nausea because you sleep through the worst of it?
I do mine Saturday mornings so if I feel crappy I have the weekend to deal with it. Some people swear by evening injections so you sleep through the initial nausea wave. Honestly, semaglutide has a half-life of about 168 hours (a full week), so the drug levels stay pretty stable — the nausea isn't really about peak levels, it's more of an initial GI adjustment thing.
Just pick a day and time that works for you and stay consistent. The most important thing is not missing doses.
ngl I was expecting way worse based on TikTok horror stories. My first month on 0.25 I had literally zero side effects. Like nothing. I actually called my pharmacy to make sure I got the real stuff lmao
It wasn't until 1.0 that I really felt it kick in. So don't panic if the first month feels like nothing is happening.
PeptideDetective — Independent Peptide Analytics
Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.
View ResultsSince we're talking expectations, here's a rough timeline of what the STEP trials showed for average weight loss at each phase. Keep in mind these are AVERAGES — individual results vary wildly:
| Timepoint | Dose | Avg Weight Loss (% body weight) | Notes |
|---|---|---|---|
| Week 4 | 0.25mg | ~1.5% | Sub-therapeutic dose |
| Week 8 | 0.5mg | ~3.5% | Appetite effects begin |
| Week 16 | 1.0-1.7mg | ~7-8% | Significant reduction in food noise |
| Week 28 | 2.4mg | ~10-12% | Nearing plateau for many |
| Week 68 | 2.4mg | ~14.9% | STEP 1 endpoint |
So for the OP at 224lbs, a "typical" STEP-1-like result would be roughly 33lbs over 68 weeks. But there's huge variance — about a third of participants lost >20% body weight.[1]
You guys are amazing. I feel so much more prepared now. I'm going to do my first injection Saturday morning, have ginger candies ready, fiber supplements on order, and a big water bottle charged up.
I'll report back next week with how it goes. Wish me luck! 🤞