Dr.RaviCardio said:The dose-response is real but shallow at the top.
Agreed, and ALT falling is not the same as fibrosis improving. Enzymes are a crude proxy; FIB-4 or elastography is what tells you about the thing that matters.
Ask again with the specifics and you will get a better answer than this one.
Dr.RaviCardio said:The dose-response is real but shallow at the top.
Thank you for spelling out the reasoning rather than just the conclusion. Adding it to my notes with a link back to this thread.
Adding the clinical framing, because it changes how the question reads. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.
That is the short version; the long version is somebody else's post.
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Shop Reference StandardsMASHdoc_SA said:It is worth asking what the claim would look like if it were false.
Adding a me-too, because a thread of one person's experience is not much use. The detail I would add is minor and it is already implied above.
MASHdoc_SA said:It is worth asking what the claim would look like if it were false.
Adding the part of the answer the thread has not reached. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.