sarah_TO said:Sharing my comprehensive lab data relevant to lean mass: Biomarker Baseline Month 3 Month 6 Month 9 Weight (lbs) 273 238 223 213 A1C (%) 7.8 6.3 6.2…
This matches mine closely enough to be worth saying so out loud. Posting only so the count is not one.
josh_phd_bmore said:Regarding lean mass: I accidentally injected my dose intramuscularly instead of subcutaneously last week (went in at wrong angle, too deep).
Physical therapist weighing in on lean mass. I work with bariatric and metabolic patients daily.
The resistance training evidence is critical here:
The Lundgren 2024 JAMA paper[1] showed that structured resistance training preserved 73% more lean mass in GLP-1 patients vs medication alone. When discussing lean mass, we MUST include the exercise component.
My minimum prescription: 3x/week compound movements (squat, deadlift, press, row), progressive overload, 7-10K steps/day, and 1.2-1.6g protein/kg/day.
[1] Lundgren JR, et al. JAMA. 2024;331(1):38-48.
josh_phd_bmore said:Regarding lean mass: I accidentally injected my dose intramuscularly instead of subcutaneously last week (went in at wrong angle, too deep).
Body composition tracking via bioimpedance on lean mass (InBody scan every 3 months):
| Metric | Baseline | Month 3 | Month 6 | Month 9 |
|---|---|---|---|---|
| Skeletal Muscle (lbs) | 69 | 67 | 69 | 73 |
| Body Fat (lbs) | 106 | 71 | 61 | 41 |
| Body Fat % | 41% | 32% | 26% | 20% |
| Visceral Fat (cm²) | 166 | 111 | 86 | 56 |
Note: skeletal muscle mass dipped initially then recovered with consistent resistance training + high protein. The visceral fat reduction is where the metabolic magic happens.
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Browse GL BiochemOne thing that is still open after josh_phd_bmore’s answer:
Was that from a primary source or from a summary of one?