Dr.NephBHM_UK said:The mechanism and the magnitude are separate questions.
Coming at Dr.NephBHM_UK’s question from a different direction. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.
Adding the numbers, since they settle part of this. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.
Sigma-Aldrich — Research-Grade Standards
Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.
Shop Reference StandardsTrialTracker_MD said:If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.
This is where I part company with the consensus forming above. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.
TrialTracker_MD said:If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.
Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.