DeniseRN_TPA said:Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
Dr.KarenChen said:Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak.
Bookmarking. The distinction being drawn above is the one nobody else makes. Taking it to my next appointment.
DeniseRN_TPA said:Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…
I will push back on the "any working dose is fine" framing. The maintenance evidence sits overwhelmingly at the top studied dose, and the extension data shows regain tracking dose reduction rather than tracking stopping. Holding low is reasonable; pretending it is evidentially equivalent is not.
Sigma-Aldrich — Research-Grade Standards
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Shop Reference StandardsOne concrete data point for the thread. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.
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