Dr.MetabolicMD said:Acid reflux and constipation: I developed GERD symptoms around week 6 that I'd never had before.
Drug interaction alert relevant to constipation: if you take oral levothyroxine (Synthroid), GLP-1 agonists can reduce absorption due to delayed gastric emptying. My TSH drifted up after starting semaglutide.
Solution: take levothyroxine on an empty stomach, 60 minutes before any food, and have your TSH rechecked 6-8 weeks after starting or changing GLP-1 dose. My endo had to increase my Synthroid by 12.5mcg.
VendorMark said:Sulfur burps on constipation — the most underrated side effect nobody warned me about.
This is exactly what I could not find anywhere else. Printing the relevant bit and taking it with me.
Dr.MetabolicMD said:Acid reflux and constipation: I developed GERD symptoms around week 6 that I'd never had before.
Gastroparesis symptoms with constipation: the delayed gastric emptying from GLP-1 agonists can cause early satiety, bloating, and feeling "full" for hours after a small meal.
Tips: eat your protein FIRST (most important macro), then vegetables, then carbs last. Chew thoroughly — 20-30 chews per bite isn't excessive. Avoid carbonated beverages with meals. If symptoms are severe, your doctor may recommend a gastric emptying study.
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