roxy_nash said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.
BiostatsBrad said:Genuine plateaus happen too, and the mechanism is metabolic adaptation plus a smaller body.
That reframing is the part I needed. Printing the relevant bit and taking it with me.
roxy_nash said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
I read this differently from roxy_nash, on substance rather than tone. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.
Sigma-Aldrich — Research-Grade Standards
Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.
Shop Reference StandardsThe figures, for anyone assembling their own picture. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.