My reason for being on this is cardiovascular rather than cosmetic, which puts me in a small minority in most of these threads.
What I am trying to establish is how much of the SELECT benefit is plausibly independent of the weight loss, and whether that distinction changes anything practical.
If the honest answer is that nobody knows, that is a useful answer and I would rather have it.
COA_Karl said:My reason for being on this is cardiovascular rather than cosmetic, which puts me in a small minority in most of these threads.
6 month update on cardiovascular risk: down 46 lbs, off blood pressure meds, A1C normalized. Genuinely life-changing.
Dr.GutHealth said:6 month update on cardiovascular risk: down 46 lbs, off blood pressure meds, A1C normalized.
Lp(a) and cardiovascular risk: a nuance that matters. Unlike most lipid markers, Lp(a) is 90%+ genetically determined and doesn't really change with weight loss or GLP-1 therapy.
My Lp(a) has remained at 62 nmol/L across all time points. If yours is elevated (>50 nmol/L), you need additional risk mitigation strategies regardless of your GLP-1 response. Don't assume your medication is covering all cardiovascular risk factors.
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Browse GL BiochemCOA_Karl said:My reason for being on this is cardiovascular rather than cosmetic, which puts me in a small minority in most of these threads.
Adding a me-too, because a thread of one person's experience is not much use. The detail I would add is minor and it is already implied above.
From the other side of the consultation, briefly.
Dizziness and cardiovascular risk: I was lightheaded for the first 2 weeks. Root cause was a combination of reduced caloric intake and mild dehydration.
Fix: minimum 80-100oz water daily, don't skip meals even if you're not hungry (eat small protein-rich snacks), and stand up slowly from sitting/lying positions. Also check your blood pressure — GLP-1-induced weight loss can make BP meds too strong, requiring dose reduction.