TrialNerd_Beth said:anders_CPH said: ...cardiovascular risk is just another fad...
Same experience, arrived at from the opposite direction.
TrialNerd_Beth said:anders_CPH said: ...cardiovascular risk is just another fad...
I want to bring up the cardiovascular angle on cardiovascular risk.
The SELECT trial demonstrated a 20% reduction in MACE with semaglutide 2.4mg[1]. This is practice-changing because the CV benefit appears to be independent of the degree of weight loss — suggesting direct vascular and anti-inflammatory mechanisms.
For cardiovascular risk, this means we need to think beyond the primary outcome and consider the cardiovascular implications. The all-cause mortality reduction (HR 0.81) is the most clinically meaningful signal.
[1] Lincoff AM, et al. N Engl J Med. 2023;389(24):2221-2232.
TrialNerd_Beth said:anders_CPH said: ...cardiovascular risk is just another fad...
Senior perspective on cardiovascular risk: I'm 69 years old and started this journey skeptically. My geriatrician recommended it after years of failed interventions.
9 months later: down 47 lbs, more mobile, pain reduced, medications simplified. My quality of life has improved dramatically. I wish this existed 20 years ago.
To other older adults hesitating: the SELECT trial proved benefit in our age group. You deserve to feel good in your body regardless of age.
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Browse GL BiochemFollowing on from TrialNerd_Beth — and this may be the naive question:
Was that from a primary source or from a summary of one?
PeptideSynthNJ said:Senior perspective on cardiovascular risk: I'm 69 years old and started this journey skeptically.
6 month update on cardiovascular risk: down 48 lbs, off blood pressure meds, A1C normalized. Genuinely life-changing.