From the other side of the consultation, briefly.
Anti-inflammatory mechanisms of GLP-1 agonists and cardiovascular risk: beyond weight loss, GLP-1R activation directly suppresses NF-κB signaling, reduces NLRP3 inflammasome activation, and decreases monocyte/macrophage adhesion to endothelium[1].
Clinical correlates: hsCRP reduction of 30-60% (consistently seen across trials), reduced carotid intima-media thickness, and decreased coronary plaque inflammation on PET imaging.
These anti-inflammatory effects likely contribute to the cardiovascular benefit seen in SELECT — and may explain benefits beyond what weight loss alone would predict.
[1] Hogan AE, et al. Diabetologia. 2014;57(4):781-784.
jason_paloalto said:NNT calculation for cardiovascular risk clinical endpoints: NNT = 1/ARR (absolute risk reduction).
6 month update on cardiovascular risk: down 64 lbs, off blood pressure meds, A1C normalized. Genuinely life-changing.
One thing that is still open after jason_paloalto’s answer:
Did your prescriber agree with that reading, and if not what was their objection?
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Browse GL Biochembri_stats said:6 month update on cardiovascular risk: down 64 lbs, off blood pressure meds, A1C normalized.
Senior perspective on cardiovascular risk: I'm 63 years old and started this journey skeptically. My geriatrician recommended it after years of failed interventions.
13 months later: down 36 lbs, more mobile, pain reduced, medications simplified. My quality of life has improved dramatically. I wish this existed 20 years ago.
To other older adults hesitating: the SELECT trial proved benefit in our age group. You deserve to feel good in your body regardless of age.
Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Tagging this one for the weekly digest.