From the other side of the consultation, briefly. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
Adding the numbers, since they settle part of this. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.
Happy to go further on any of that.
A narrower follow-up, since the general answer is now clear:
Did your prescriber agree with that reading, and if not what was their objection?
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Shop Reference StandardsTirzTom said:If you are going to change something, change one thing and give it long enough to express itself.
Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Steady state is the thing most people miss. The terminal half-life is about a week, so every dose step takes four to five weeks to fully express itself. Judging a step at day ten is judging the ascent, not the plateau, and it is the single commonest reason people escalate before they needed to.
Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Carry on.